肺炎球菌LytA自溶素，一种在由高度耐β-内酰胺类的肺炎链球菌引起的实验性腹膜炎-脓毒症中有效的治疗剂。
Pneumococcal LytA autolysin, a potent therapeutic agent in experimental peritonitis-sepsis caused by highly beta-lactam-resistant Streptococcus pneumoniae.
作者信息
Rodríguez-Cerrato Violeta, García Pedro, Huelves Lorena, García Ernesto, Del Prado Gema, Gracia Matilde, Ponte Carmen, López Rubens, Soriano Francisco
机构信息
Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3371-3. doi: 10.1128/AAC.00137-07. Epub 2007 Jun 18.
Abstract
The in vitro and in vivo antipneumococcal activities of the main pneumococcal autolysin (LytA) and Cpl-1, a lysozyme encoded by phage Cp-1, were studied. Intraperitoneal therapy with LytA or high-dose Cpl-1 remarkably reduced peritoneal bacterial counts (>5 log(10) CFU/ml) compared with those for the controls. After intravenous injection, LytA was the most effective treatment.
摘要
研究了主要肺炎球菌自溶素（LytA）和噬菌体Cp-1编码的溶菌酶Cpl-1的体外和体内抗肺炎球菌活性。与对照组相比，腹腔注射LytA或高剂量Cpl-1可显著降低腹腔细菌计数（>5 log₁₀ CFU/ml）。静脉注射后，LytA是最有效的治疗方法。
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