Allegra A, Oteri G, Nastro E, Alonci A, Bellomo G, Del Fabro V, Quartarone E, Alati C, De Ponte F S, Cicciù D, Musolino C
Division of Haematology, University of Messina, Italy.
Hematol Oncol. 2007 Dec;25(4):164-9. doi: 10.1002/hon.819.
Osteonecrosis of the jaws (ONJ) associated with the use of bisphosphonates is a newly described entity. To elucidate the mechanism leading to ONJ and to test the hypothesis that in patients with ONJ the bisphosphonates may interfere with endothelial cell proliferation, using flow cytometric analysis we evaluated the number of circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in eight patients with bisphosphonate treatment and osteonecrosis, eight multiple myeloma (MM) patients with bisphosphonates treatment without ONJ and five normal subjects. MM patients showed an increase of CD34+ cells with respect the control subjects and ONJ subjects. EPCs and CECs were higher in MM patients compared to controls and ONJ patients. ONJ patients showed a decrease of EPCs compared to control subjects while CECs were similar to the controls group. Our results seem to show the possibility that bisphosphonates could have a antiangiogenic effect and a suppressive effect on CECs of patients with ONJ.
与双膦酸盐使用相关的颌骨骨坏死（ONJ）是一种新描述的病症。为了阐明导致ONJ的机制，并检验ONJ患者中双膦酸盐可能干扰内皮细胞增殖这一假说，我们使用流式细胞术分析评估了8例接受双膦酸盐治疗且发生骨坏死的患者、8例接受双膦酸盐治疗但未发生ONJ的多发性骨髓瘤（MM）患者以及5名正常受试者的循环内皮祖细胞（EPCs）和循环内皮细胞（CECs）数量。与对照受试者和ONJ受试者相比，MM患者的CD34 +细胞有所增加。与对照组和ONJ患者相比，MM患者的EPCs和CECs更高。与对照受试者相比，ONJ患者的EPCs减少，而CECs与对照组相似。我们的结果似乎表明双膦酸盐可能对ONJ患者的CECs具有抗血管生成作用和抑制作用。
