唑来膦酸治疗大鼠模型中颌骨和股骨中成血管标志物的表达。
Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid.
机构信息
Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Department of Orthodontics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
出版信息
BMC Res Notes. 2022 Jan 10;15(1):12. doi: 10.1186/s13104-021-05900-5.
OBJECTIVES
This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid.
RESULTS
No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in both ZA group (3 in mandible, 4 in maxilla) and control group (1 in mandible, 2 in maxilla), while exposed bone was found only in the ZA group (1 in maxilla, 2 in mandible). RT-PCR analysis demonstrated no significant difference in gene expression of angiogenetic markers between ZA-treated and control groups in femur and mandible. In the maxilla, the expression of VEGFA and VEGFR-2 in medium-term ZA group was significantly down-regulated compared with that in the control. The ZA treatment does not change significantly the expression of the angiogenic factors in femur and mandible, but significantly downregulates the expression in maxilla in this rat model. The angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role.
目的
本研究旨在探讨给予唑来膦酸的大鼠模型中手术治疗的颌骨和股骨中的血管生成标记物的基因表达。
结果
在股骨中未发现软组织窗或骨暴露。在 ZA 组（下颌骨 3 例，上颌骨 4 例）和对照组（下颌骨 1 例，上颌骨 2 例）中均发现软组织愈合延迟，而仅在 ZA 组（上颌骨 1 例，下颌骨 2 例）中发现暴露的骨。RT-PCR 分析表明，在股骨和下颌骨中，血管生成标记物的基因表达在 ZA 治疗组与对照组之间无显著差异。在上颌骨中，与对照组相比，中期 ZA 组 VEGFA 和 VEGFR-2 的表达显著下调。在该大鼠模型中，ZA 治疗不会显著改变股骨和下颌骨中血管生成因子的表达，但会显著下调上颌骨中的表达。血管生成抑制可能有助于 MRONJ 的发生，但不是关键作用。
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