Bäckman K, Jontell M
Clinic of Oral Medicine, Public Dental Health, Göteborg, Sweden.
Oral Dis. 2007 Jul;13(4):402-6. doi: 10.1111/j.1601-0825.2006.01312.x.
The objective of the present study was to compare a new type of symptomatic lichenoid reaction, specifically located on the mucosal side of the lips, and associated with microorganisms, with a matched group presenting with reticular oral lichen planus (OLP) of the buccal mucosa.
The mean age for both groups was 66 years with a predominance of women (62%). The lichenoid reaction group (n = 25) presented with a reticular reaction pattern embracing various degrees of erythema. Patients presenting with OLP had similar lesions confined to the buccal mucosa but not on the mucosal side of the lips.
In both groups, 80% were on any type of medication. However, 56% of the patients with lichenoid reactions medicated with more than three drugs compared with 29% (P < 0.05) in the OLP group. The former group more often used medicaments prescribed for cardiovascular diseases (48%vs 25%). Twenty-two of the patients with lichenoid reactions were treated with chlorhexidine. In 80% of these patients (n = 18), the lesions improved or completely healed, indicating a microbial association.
Lichenoid reactions present on the mucosal side of the lips may be initiated by microbial plaque precipitated on the buccal surfaces of the anterior teeth.
本研究的目的是比较一种新型的症状性苔藓样反应，该反应具体位于嘴唇黏膜侧，且与微生物有关，与一组匹配的患有颊黏膜网状口腔扁平苔藓（OLP）的患者进行对比。
两组患者的平均年龄均为66岁，女性占多数（62%）。苔藓样反应组（n = 25）呈现出包含不同程度红斑的网状反应模式。患有OLP的患者有类似病变，但局限于颊黏膜，而非嘴唇黏膜侧。
两组中80%的患者正在服用任何类型的药物。然而，苔藓样反应患者中有56%服用三种以上药物，而OLP组为29%（P < 0.05）。前一组更常使用治疗心血管疾病的药物（48%对25%）。22例苔藓样反应患者接受了氯己定治疗。在这些患者中的80%（n = 18），病变得到改善或完全愈合，表明与微生物有关。
嘴唇黏膜侧出现的苔藓样反应可能由前牙颊面沉淀的微生物菌斑引发。
