Zachariae Claus, Engkilde Kåre, Johansen Jeanne Duus, Menné Torkil
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Contact Dermatitis. 2007 Jun;56(6):344-6. doi: 10.1111/j.1600-0536.2007.01122.x.
Primin was included in the European standard series (ESS) in 1984. In 2000, a primin-free variant of Primula obconica, the main source of contact allergy to primin, was introduced in the market. The aim of this study was to analyse the trends of primin allergy in 13 986 consecutively patch-tested eczema patients over a 20-year period from 1985 to 2004. 151 patients gave a positive patch test to primin. The majority were women, in two-third of patients the patch test was relevant and most presented with hand eczema. Only few of the cases (4.7%) were occupational. A significant decline of contact allergy to primin was seen (P < 0.001) over the years affecting all age groups. The frequency was 0.5% during 2000-2004. Contact allergy has been rare since 2000. The low frequency of positive patch test to primin does not support inclusion in the ESS in our region.
1984年，樱草素被纳入欧洲标准系列（ESS）。2000年，报春花（樱草素接触性过敏的主要来源）的一种不含樱草素的变种投放市场。本研究的目的是分析1985年至2004年期间13986例连续接受斑贴试验的湿疹患者中樱草素过敏的趋势。151例患者斑贴试验对樱草素呈阳性。大多数为女性，三分之二的患者斑贴试验结果具有相关性，且大多数表现为手部湿疹。只有少数病例（4.7%）与职业有关。多年来，各年龄组对樱草素的接触性过敏均显著下降（P<0.001）。2000 - 2004年期间频率为0.5%。自2000年以来，接触性过敏一直很少见。斑贴试验对樱草素呈阳性的频率较低，不支持在我们地区将其纳入ESS。
