Vahid Bobbak, Bibbo Marluce, Marik Paul E
Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, USA.
Scand J Infect Dis. 2007;39(6-7):612-4. doi: 10.1080/00365540601115946.
We described the characteristics of bronchoalveolar inflammatory cells and their correlation with lung injury in patients with Pneumocystis jiroveci pneumonia. We reviewed all cases of patients with Pneumocystis jiroveci pneumonia in newly diagnosed HIV infected patients admitted to a large metropolitan referral hospital during June 2003 to December 2004. Nine patients (5M, 4F) with Pneumocystis jiroveci pneumonia diagnosed with bronchoscopy and cytological examination of bronchoalveolar lavage (BAL) were identified. There was a positive correlation between peripheral CD8 count and BAL neutrophilia and negative correlation with hypoxemia. Although the number patients in this case series is small, our findings suggest that CD8 cells and alveolar neutrophilic inflammation have a role in lung injury in Pneumocystis jiroveci pneumonia. These findings are consistent with data from animal studies.
我们描述了耶氏肺孢子菌肺炎患者支气管肺泡炎症细胞的特征及其与肺损伤的相关性。我们回顾了2003年6月至2004年12月期间入住一家大型都市转诊医院的新诊断HIV感染患者中所有耶氏肺孢子菌肺炎病例。通过支气管镜检查和支气管肺泡灌洗（BAL）细胞学检查确诊了9例（5例男性，4例女性）耶氏肺孢子菌肺炎患者。外周血CD8计数与BAL中性粒细胞增多呈正相关，与低氧血症呈负相关。尽管该病例系列中的患者数量较少，但我们的研究结果表明，CD8细胞和肺泡中性粒细胞炎症在耶氏肺孢子菌肺炎的肺损伤中起作用。这些发现与动物研究数据一致。
