What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets.
作者信息
Beckwith Jon
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Genetics. 2007 Jun;176(2):733-40. doi: 10.1534/genetics.107.076240.
Abstract
摘要
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What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets.天王星之外是什么？探索生物学奥秘过程中的先入之见、无知、意外发现和抑制因素。
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The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain.还原多肽链氧化过程中天然核糖核酸酶的形成动力学。
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Production of functional single-chain Fv antibodies in the cytoplasm of Escherichia coli.在大肠杆菌细胞质中生产功能性单链Fv抗体。
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Conversion of a peroxiredoxin into a disulfide reductase by a triplet repeat expansion.通过三联体重复序列扩增将过氧化物还原酶转化为二硫键还原酶。
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AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.AhpF可被分解为两个功能单元：N端两个硫氧还蛋白样折叠的串联重复序列介导电子从硫氧还蛋白还原酶样C端传递至AhpC。
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Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm.在大肠杆菌细胞质中高效折叠具有多个二硫键的蛋白质。
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