Loo Sandra K, Smalley Susan L
Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):107-9. doi: 10.1002/ajmg.b.30575.
The purpose of the present study is to examine the familiality of electroencephalographic (EEG) measures among affected sibling pairs with Attention-Deficit Hyperactivity Disorder (ADHD). EEG was recorded during baseline (eyes open and eyes closed) and cognitive activation conditions on a sample of 58 children with ADHD (27 multiplex families), ages 6-18. EEG power in three frequency bands: theta (4-7 Hz), alpha (8-12 Hz) and beta (12-20 Hz) was tested for sibling correlation, familial co-segregation and association with behavioral task performance on a sustained attention task. Sibling correlation for EEG measures was moderate during baseline conditions and significantly higher for the cognitive activation condition. Familial clustering of frontal and parietal alpha power was evident, but only during the cognitive activation condition. Theta and alpha power correlated significantly with CPT response variability and omission errors, respectively. Cognitive task performance did not exhibit familial clustering in our sample. EEG measures (i.e., alpha power) recorded during cognitive activation is a strongly familial trait in ADHD and may be a putative endophenotype for ADHD.
本研究的目的是检验注意缺陷多动障碍（ADHD）患病同胞对之间脑电图（EEG）测量指标的家族聚集性。对58名年龄在6至18岁的ADHD儿童（来自27个多重家庭）样本，在基线状态（睁眼和闭眼）以及认知激活状态下记录EEG。测试了三个频段（θ波（4 - 7Hz）、α波（8 - 12Hz）和β波（12 - 20Hz））的EEG功率，以分析同胞相关性、家族共分离以及与持续性注意任务中行为任务表现的关联。在基线状态下，EEG测量指标的同胞相关性中等，而在认知激活状态下显著更高。额叶和顶叶α波功率的家族聚集现象明显，但仅在认知激活状态下出现。θ波和α波功率分别与连续性能测试（CPT）的反应变异性和遗漏错误显著相关。在我们的样本中，认知任务表现未呈现家族聚集性。认知激活期间记录的EEG测量指标（即α波功率）在ADHD中是一种强家族性特征，可能是ADHD的一种假定内表型。
