Clarke Adam R, Barry Robert J, McCarthy Rory, Selikowitz Mark, Clarke Donna C, Croft Rodney J
Brain and Behaviour Research Institute, University of Wollongong, Wollongong 2522, Australia.
Clin Neurophysiol. 2003 Sep;114(9):1729-37. doi: 10.1016/s1388-2457(03)00112-3.
This study investigated the effects of stimulant medications on the Electroencephalography (EEG) of children with the combined type of attention-deficit/hyperactivity disorder (ADHD) together with excessive beta activity in their EEG.
Twenty ADHD and 20 control subjects participated in this study. EEG was recorded from 21 sites during an eyes-closed resting condition and Fourier transformed to provide estimates for total power and absolute and relative power in the delta, theta, alpha and beta bands, and for the theta/alpha and theta/beta ratios. Subjects were placed on a 6-month trial of a stimulant medication and a second EEG was recorded at the end of the trial.
The unmedicated ADHD group had greater absolute and relative beta, less absolute and relative alpha, a higher theta/alpha and a lower theta/beta ratio than the control group. In the frontal regions the ADHD group had an increase in total power, absolute theta, absolute and relative beta and the theta/beta ratio, with greater relative delta, relative theta, and absolute and relative alpha in posterior regions. With medication use, absolute beta activity and frontal total power decreased, although these changes represented a reduction in power, not a normalisation.
These results indicate that ADHD children with excessive beta activity in their EEG are probably not hypoaroused as previously suggested, and that beta activity in these children is probably only associated with the impulsivity and/or hyperactivity aspects of the disorder, but may not necessarily be associated with inattention.
This study is the first to investigate effects of stimulant medications on the EEG of ADHD children with excessive beta activity in their EEG.
本研究调查了兴奋剂药物对注意力缺陷多动障碍（ADHD）混合型儿童脑电图（EEG）的影响，这些儿童的脑电图中存在过度的β波活动。
20名ADHD患儿和20名对照受试者参与了本研究。在闭眼静息状态下从21个部位记录脑电图，并进行傅里叶变换，以提供δ波、θ波、α波和β波频段的总功率、绝对功率和相对功率估计值，以及θ/α和θ/β比值。受试者接受了为期6个月的兴奋剂药物试验，并在试验结束时记录了第二次脑电图。
未用药的ADHD组比对照组具有更高的绝对和相对β波、更低的绝对和相对α波、更高的θ/α比值和更低的θ/β比值。在额叶区域，ADHD组的总功率、绝对θ波、绝对和相对β波以及θ/β比值增加，而后部区域的相对δ波、相对θ波以及绝对和相对α波更大。使用药物后，绝对β波活动和额叶总功率降低，尽管这些变化代表功率降低，而非正常化。
这些结果表明，脑电图中存在过度β波活动的ADHD儿童可能并不像之前所认为的那样唤醒不足，并且这些儿童的β波活动可能仅与该疾病的冲动性和/或多动方面相关，但不一定与注意力不集中相关。
本研究首次调查了兴奋剂药物对脑电图中存在过度β波活动的ADHD儿童脑电图的影响。
