Holzer T J, Heynen C A, Kennedy M M, Peterson D A
Department of Experimental Biology Research, Abbott Laboratories, Inc., North Chicago, IL.
J Med Primatol. 1991 Aug;20(6):295-301.
Peripheral blood mononuclear cells (MNC) from three chimpanzees infected with hepatitis C virus (HCV) and from two uninfected animals were analyzed by monoclonal antibody phenotyping using flow cytometry. Significant differences in numbers of MNC's expressing cluster designation (CD) phenotypes CD4, CD14, CD19, and CD45RA were found. Additionally, significant differences in MNC proliferation in response to mitogens were also found. This altered proliferative capacity and cellular phenotype profile may be important markers in studying the pathogenesis of chronic HCV disease.
使用流式细胞术通过单克隆抗体表型分析对三只感染丙型肝炎病毒（HCV）的黑猩猩和两只未感染动物的外周血单个核细胞（MNC）进行了分析。发现表达簇分化抗原（CD）表型CD4、CD14、CD19和CD45RA的MNC数量存在显著差异。此外，还发现MNC对有丝分裂原反应的增殖存在显著差异。这种改变的增殖能力和细胞表型谱可能是研究慢性HCV疾病发病机制的重要标志物。
