Sanchez Rosa, Bacchetti Peter, Toy Pearl
Department of Laboratory Medicine, University of California San Francisco, CA 94143, USA.
Am J Clin Pathol. 2007 Jul;128(1):128-34. doi: 10.1309/HC4PVY24NJXMQ884.
Transfusion-related acute lung injury (TRALI) is the leading cause of mortality from transfusion therapy. Recipient, donor, and blood product risk factors may have important roles in the occurrence of TRALI. A case-control pilot study of 6 TRALI cases in which HLA-antibody concordance was found and 20 control subjects was conducted to evaluate recipient and donor predictors of TRALI. By using stratified exact logistic regression, characteristics of the recipients, donors, and blood products were analyzed and the results reported as odds ratios. The risk for TRALI was increased per unit of whole blood transfused (odds ratio, 3.0 per unit; P = .0098). A larger prospective case-control study is underway to determine recipient, donor, and blood product risk factors associated with TRALI.
输血相关急性肺损伤（TRALI）是输血治疗导致死亡的主要原因。受血者、供血者及血液制品的危险因素可能在TRALI的发生中起重要作用。开展了一项病例对照试点研究，纳入6例发现HLA抗体一致性的TRALI病例及20例对照受试者，以评估TRALI的受血者和供血者预测因素。通过使用分层精确逻辑回归分析受血者、供血者及血液制品的特征，并将结果报告为比值比。每输注一个单位全血，TRALI风险增加（比值比，每单位3.0；P = .0098）。一项规模更大的前瞻性病例对照研究正在进行，以确定与TRALI相关的受血者、供血者及血液制品危险因素。
