Oswell G, Kaunisto M A, Kallela M, Hämäläinen E, Anttila V, Kaprio J, Färkkilä M, Wessman M, Palotie A
The Finnish Genome Center, University of Helsinki, Helsinki, Finland.
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):33-6. doi: 10.1002/ajmg.b.30566.
To date, no gene variants predisposing to common forms of migraine have been convincingly identified. Recently, significant linkage to a cluster of gamma-amino butyric acid (GABA)-A receptors on Chr 15q11-q13 was reported. We performed an extensive association study using 898 MA cases and 900 matched controls by covering the same gene cluster with 34 single nucleotide polymorphisms (SNPs). No association to MA was detected, suggesting that common variants of the GABA cluster are unlikely to be major contributors of MA susceptibility.
迄今为止，尚未令人信服地鉴定出易患常见偏头痛类型的基因变异。最近，有报道称与15号染色体q11-q13上的一组γ-氨基丁酸（GABA）-A受体存在显著连锁。我们通过用34个单核苷酸多态性（SNP）覆盖同一基因簇，对898例偏头痛（MA）患者和900例匹配对照进行了广泛的关联研究。未检测到与MA的关联，这表明GABA簇的常见变异不太可能是MA易感性的主要贡献因素。
