SEIN Epilepsy Institute in the Netherlands Foundation, Heemstede, The Netherlands, P.O. Box 540, 2130 AM, Hoofddorp, The Netherlands.
Curr Pain Headache Rep. 2013 Aug;17(8):351. doi: 10.1007/s11916-013-0351-x.
Headache and epilepsy often co-occur. Epidemiologic studies conducted in the past few years reinforce the notion of a bi-directional association between migraine and epilepsy. Data on an association between headache (in general) and epilepsy, however, are less clear. Peri-ictal headache often presents with migraine-like symptoms and can be severe. A correct diagnosis and management are paramount. It was demonstrated that cortical hyperexcitability may underlie both epilepsy and migraine. A recent study linked spreading depolarisation, the supposed underlying pathophysiological mechanism of migraine with aura, to epilepsy. Although this study was carried out in patients who had suffered a subarachnoid haemorrhage, the finding may shed light on pathophysiological mechanisms common to epilepsy and migraine.
头痛和癫痫常常同时发生。过去几年进行的流行病学研究强化了偏头痛和癫痫之间存在双向关联的观点。然而，关于头痛（一般而言）和癫痫之间关联的数据则不太明确。发作期头痛常表现出类似偏头痛的症状，且可能很严重。正确的诊断和治疗至关重要。皮质过度兴奋可能是癫痫和偏头痛的共同基础，这一点已得到证实。最近的一项研究将偏头痛先兆的假定潜在病理生理学机制——扩散性去极化与癫痫联系起来。尽管这项研究是在蛛网膜下腔出血的患者中进行的，但这一发现可能为癫痫和偏头痛的共同病理生理学机制提供线索。
