Cell metabolism of acyclovir phosphonate derivatives and antiherpesvirus activity of their combinations with alpha2-interferon.
作者信息
Skoblov Yuri S, Karpenko Inna L, Jasko Maxim V, Kukhanova Marina K, Andronova Valery L, Galegov Georgy A, Sidorov Georgy V, Myasoedov Nicolai F
机构信息
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov str., Moscow 119991, Russian Federation.
出版信息
Chem Biol Drug Des. 2007 Jun;69(6):429-34. doi: 10.1111/j.1747-0285.2007.00517.x.
The combinational use of acyclovir (ACV) phosphonate esters and alpha(2)-interferon was shown to produce a synergistic effect on inhibition of HSV-1 replication in Vero cell cultures. Unlike other acyclovir phosphonate derivatives studied earlier, ACV H-phosphonate is not an ACV prodrug. On penetrating into the cells, it may be directly converted into ACV monophosphate escaping dephosphonylation-phosphorylation steps.
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