Zhou Yi, Jiang Shun-Yuan, Sun Hui, Yang An-Dong, Ma Yan, Ma Xiao-Jun, Wu Rui
Sichuan Institute of Chinese Materia Medica, Chengdu 610041, China.
Zhongguo Zhong Yao Za Zhi. 2007 Apr;32(7):566-9.
To establish scientific and efficient quality control standard of Rhizoma et Radix Notopterygii through two quantitative parameters.
The contents of isoimperatorin and volatile oils in 29 commercial samples from 22 localities of Rhizoma et Radix Notopterygii were determined by HPLC and the method in the pharmacopoeia respectively. The data were statistically analyzed.
Only 3 of 29 samples met the required standard in the Chinese Pharmacopoeia (2005 edition), 87% of samples newly produced in 2005 not met the standard. Statistics showed that the contents of volatile oils and isoimperatorin should reach 1.63% and 0.17% respectively when the samples meet requirement of criterion with more than 80% probability. The contents of volatile oil and isoimperatorin were not significantly different (P < 0.05) in the samples of 2005 and 2003, while the contents of isoimperatorin were significantly different between Notopterygium incisum and N. forbesii samples.
Since the criterion of volatile oils in the Chinese Pharmacopoeia (2005 version) for Rhizoma et Radix Notopterygii is too high to satisfy for most Rhizoma et Radix Notopterygii samples, it is suggested to reduce it to 1.6% (mL x g(-1)). The content of isoimperatorin is proposed to add to the quality standard of Rhizoma et Radix Notopterygii as above 0.2% (mg x g(-1)).
通过两个定量参数建立羌活科学、高效的质量控制标准。
分别采用高效液相色谱法和药典方法测定来自22个产地的29批羌活商品样品中异欧前胡素和挥发油的含量，并进行统计学分析。
29批样品中仅3批符合《中国药典》（2005年版）规定标准，2005年新产样品87%不符合标准。统计显示，当样品以超过80%的概率符合标准时，挥发油和异欧前胡素含量应分别达到1.63%和0.17%。2005年和2003年样品中挥发油含量无显著差异（P<0.05），而异欧前胡素含量在羌活和宽叶羌活样品间有显著差异。
由于《中国药典》（2005年版）中羌活挥发油标准过高，多数羌活样品难以达到，建议将其降至1.6%（mL·g-1）。建议将异欧前胡素含量作为羌活质量标准，增加至0.2%（mg·g-1）以上。
