Jiang Shun-Yuan, Sun Hong-Bing, Sun Hui, Ma Yu-Ying, Chen Hong-Yu, Zhu Wen-Tao, Zhou Yi
Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China.
Guangdong Pharmaceutical University, Guangzhou 510000, China.
Zhongguo Zhong Yao Za Zhi. 2016 Mar;41(5):793-801. doi: 10.4268/cjcmm20160506.
This paper aims to explore a comprehensive assessment method combined traditional Chinese medicinal material specifications with quantitative quality indicators. Seventy-six samples of Notopterygii Rhizoma et Radix were collected on market and at producing areas. Traditional commercial specifications were described and assigned, and 10 chemical components and volatile oils were determined for each sample. Cluster analysis, Fisher discriminant analysis and correspondence analysis were used to establish the relationship between the traditional qualitative commercial specifications and quantitative chemical indices for comprehensive evaluating quality of medicinal materials, and quantitative classification of commercial grade and quality grade. A herb quality index (HQI) including traditional commercial specifications and chemical components for quantitative grade classification were established, and corresponding discriminant function were figured out for precise determination of quality grade and sub-grade of Notopterygii Rhizoma et Radix. The result showed that notopterol, isoimperatorin and volatile oil were the major components for determination of chemical quality, and their dividing values were specified for every grade and sub-grade of the commercial materials of Notopterygii Rhizoma et Radix. According to the result, essential relationship between traditional medicinal indicators, qualitative commercial specifications, and quantitative chemical composition indicators can be examined by K-mean cluster, Fisher discriminant analysis and correspondence analysis, which provide a new method for comprehensive quantitative evaluation of traditional Chinese medicine quality integrated traditional commodity specifications and quantitative modern chemical index.
本文旨在探索一种将中药材规格与定量质量指标相结合的综合评价方法。在市场和产地收集了76份羌活样品。描述并划分了传统商业规格，对每个样品测定了10种化学成分和挥发油。采用聚类分析、Fisher判别分析和对应分析，建立传统定性商业规格与定量化学指标之间的关系，以综合评价药材质量，并对商业等级和质量等级进行定量分类。建立了包括传统商业规格和化学成分的药材质量指数（HQI）用于定量等级分类，并得出相应判别函数以精确测定羌活药材的质量等级和亚等级。结果表明，羌活醇、异欧前胡素和挥发油是化学质量测定的主要成分，并规定了羌活商业药材各等级和亚等级的划分值。根据结果，通过K均值聚类、Fisher判别分析和对应分析，可以考察传统药用指标、定性商业规格和定量化学成分指标之间的本质关系，为结合传统商品规格和现代定量化学指标对中药质量进行综合定量评价提供了一种新方法。
