Han Lin, Dean Delphine, Mao Pan, Ortiz Christine, Grodzinsky Alan J
Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Biophys J. 2007 Sep 1;93(5):L23-5. doi: 10.1529/biophysj.107.114025. Epub 2007 Jun 22.
The nanoscale shear deformation behavior of two opposing end-grafted aggrecan layers was studied in aqueous solutions using atomic force microscopy, and was observed to depend markedly on bath ionic strength, the presence of calcium ions, and the applied lateral displacement rate. These results provide molecular-level insights into the contribution of aggrecan deformation mechanisms to cartilage tissue-level material properties.
利用原子力显微镜研究了两个相对的端接聚糖层在水溶液中的纳米级剪切变形行为，观察到其显著依赖于浴液离子强度、钙离子的存在以及施加的横向位移速率。这些结果为聚糖变形机制对软骨组织水平材料特性的贡献提供了分子水平的见解。
