Jonkers Jos, Derksen Patrick W B
Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):191-203. doi: 10.1007/s10911-007-9050-8.
Metastatic disease is the major cause of death in breast cancer patients. Patients presenting with metastases cannot be cured, and as a consequence, treatment is palliative and focuses on prolonging survival and maintaining quality of life. Numerous mouse models have been generated in which human breast cancer development and metastasis have been studied, ranging from spontaneous and carcinogen-induced models to transplantation models and genetically engineered mouse models. Here, we summarize past progress and highlight present developments in modeling breast cancer invasion and metastasis in genetically modified mice, and the impact it may have on the development of innovative anticancer therapies.
转移性疾病是乳腺癌患者死亡的主要原因。出现转移的患者无法治愈，因此，治疗是姑息性的，重点是延长生存期和维持生活质量。已经建立了许多小鼠模型，用于研究人类乳腺癌的发生和转移，从自发和致癌物诱导模型到移植模型和基因工程小鼠模型。在此，我们总结过去的进展，突出转基因小鼠中乳腺癌侵袭和转移建模的当前发展，以及它可能对创新抗癌疗法发展产生的影响。
