Sato Hirokazu, Sasaki Nozomu, Aoki Kikumaro, Kuroda Yasuhiro, Kato Tadaaki
Sunrise Children's Clinic, Funabashi Chiba, Japan.
Pediatr Int. 2007 Aug;49(4):443-6. doi: 10.1111/j.1442-200X.2007.02395.x.
The growth of patients with congenital hypothyroidism detected by neonatal screening in Japan was investigated. The data investigated were obtained from Medical Aid Program for Chronic Pediatric Diseases of Specified Categories registered in 2002.
The present study included 2341 patients (1030 male, 1311 female) registered as having congenital hypothyroidism. To investigate the growth of these patients, their heights plotted on cross-sectional growth charts for boys and girls, their bodyweights expressed as percentage of bodyweight for height and the frequency distribution of percentage of bodyweight for height were assessed.
Cross-sectional growth charts of both male and female patients showed that the heights of the majority of the patients with congenital hypothyroidism were within +/-2SD. Approximately half of the patients with heights below -2SD, had some complications. The mean percentages of ideal bodyweights for height were 103.0 +/- 12.9% for both sexes (+/-SD, n = 2033), 103.3 +/- 12.7% for boys, and 102.7 +/- 12.9% for girls. The frequency distribution of percentage of bodyweight showed no tendency of shifting to either ends in comparison with normal distribution curve.
Patients with congenital hypothyroidism detected by neonatal screening had normal growth in general, suggesting that the neonatal screening system is being performed efficiently from detection to treatment of the disease in Japan. However, it remains unclear whether some uncomplicated patients with a height below -2 SD are sufficiently treated or not. Close observation of these patients may be needed.
对日本通过新生儿筛查发现的先天性甲状腺功能减退症患者的生长情况进行了调查。所调查的数据来自2002年登记的特定类别慢性儿科疾病医疗救助项目。
本研究纳入了2341例登记为先天性甲状腺功能减退症的患者（男1030例，女1311例）。为了调查这些患者的生长情况，评估了他们在男、女横断面生长图表上的身高、身高体重百分比以及身高体重百分比的频率分布。
男性和女性患者的横断面生长图表均显示，大多数先天性甲状腺功能减退症患者的身高在±2标准差范围内。身高低于-2标准差的患者中约有一半有一些并发症。身高理想体重的平均百分比，两性均为103.0±12.9%（±标准差，n=2033），男性为103.3±12.7%，女性为102.7±12.9%。体重百分比的频率分布与正态分布曲线相比没有向两端偏移的趋势。
通过新生儿筛查发现的先天性甲状腺功能减退症患者总体生长正常，这表明日本从疾病的检测到治疗的新生儿筛查系统运行有效。然而，尚不清楚一些身高低于-2标准差且无并发症的患者是否得到了充分治疗。可能需要对这些患者进行密切观察。
