Reusch Jane E-B, Draznin Boris B
Research Service of Department of Veterans Affairs, and Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA.
Diabetes Obes Metab. 2007 Jul;9(4):455-63. doi: 10.1111/j.1463-1326.2006.00620.x.
Atherosclerosis and cardiovascular disease are the major causes of morbidity and mortality in patients with diabetes and those with insulin resistance and the metabolic syndrome. Both conditions profoundly accelerate the development of atherosclerosis and increase the morbidity and mortality of cardiovascular events. The question, therefore, is what are the molecular/biochemical mechanisms that underlie the potentiating influence of diabetes, the metabolic syndrome and/or insulin resistance on the development and progression of atherosclerosis? The following review will focus on the molecular mechanism whereby hyperglycaemia and/or hyperinsulinemia either directly or indirectly promote atherosclerosis.
动脉粥样硬化和心血管疾病是糖尿病患者以及胰岛素抵抗和代谢综合征患者发病和死亡的主要原因。这两种情况都会显著加速动脉粥样硬化的发展，并增加心血管事件的发病率和死亡率。因此，问题在于糖尿病、代谢综合征和/或胰岛素抵抗对动脉粥样硬化发展和进展的增强作用背后的分子/生化机制是什么？以下综述将聚焦于高血糖和/或高胰岛素血症直接或间接促进动脉粥样硬化的分子机制。
