Koh Kwang Kon, Han Seung Hwan, Quon Michael J
Division of Cardiology, Gil Heart Center, Gachon Medical School, Incheon, Korea.
J Am Coll Cardiol. 2005 Dec 6;46(11):1978-85. doi: 10.1016/j.jacc.2005.06.082. Epub 2005 Nov 9.
Inflammation in the vasculature might be an important pathogenic link between cardiovascular diseases and the metabolic syndrome. Inflammation can be reduced by a variety of approaches including diet, exercise, cardiovascular drugs, and insulin sensitizers. Importantly, these different measures improve vascular function and reduce inflammation by distinct mechanisms. Therefore, combination therapy including lifestyle modifications and multiple drugs from separate classes might produce additive beneficial outcomes. We review plausible mechanisms for effects of combination therapy to reduce inflammation, improve endothelial dysfunction, and decrease insulin resistance in atherosclerosis, coronary heart disease, and hypertension in the context of insulin-resistant states including diabetes, obesity, and the metabolic syndrome.
血管炎症可能是心血管疾病与代谢综合征之间的重要致病联系。炎症可通过多种方法减轻，包括饮食、运动、心血管药物和胰岛素增敏剂。重要的是，这些不同措施通过不同机制改善血管功能并减轻炎症。因此，包括生活方式改变和来自不同类别的多种药物的联合治疗可能会产生累加的有益效果。我们在包括糖尿病、肥胖症和代谢综合征在内的胰岛素抵抗状态背景下，综述联合治疗在动脉粥样硬化、冠心病和高血压中减轻炎症、改善内皮功能障碍以及降低胰岛素抵抗的可能机制。
