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[委内瑞拉马拉开波非吸烟健康男性的肺容积]

[Lung volumes in non-smoking healthy men in Maracaibo, Venezuela].

作者信息

Corzo-Alvarez G R

机构信息

Instituto de Medicina del Trabajo e Higiene Industrial, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.

出版信息

Invest Clin. 1998 Mar;39(1):3-17.

PMID:9586396
Abstract

The significant applicability of the tests to measure lung volumes makes it necessary to handle them frequently and this implies the comparison of the registered values for lung function parameters with predicted or referential values which are obtained via derivate equations of healthy population studies. The Slow Vital Capacity (SVC), Inspiratory Capacity (IC), Functional Residual Capacity (FRC), Residual Volume (RV), Total Lung Capacity (TLC) and the physical characteristics, were measured in 50 healthy men, non smokers, with ages between 17 and 63 years, in order to deduce++ prediction equations. The functional tests were performed by means of the multiple respiratory technique and Helium Dilution, using a Spinnaker TL Lung Functions Analyzer. Stepwise multiple regression analyses were used to derive equations for predicting lung volumes, that allowed the inclusion of the variables that add prediction with statistical significance (95% of confidence), and obtaining for SVC: R = 0.853, SEE = 0.350 lts; IC: R = 0.822, SEE = 0.296 lts; FRC: R = 0.843, SEE = 0.326 lts; RV: R = 0.891, SEE = 0.153 lts y TLC: R = 0.883, SEE = 0.458 lts. The analysis of variance (ANOVA) was highly significant (p < 0.00001) for each one of the models of regression of the estimated parameters. The fifth percentile was considered as the lower limit of the established volume as the normal value. The calculation of fifth percentiles determined were SVC = 3.59 lts, IC = 2.47 lts, FRC = 2.14 lts, RV = 1.26 lts, and TLC = 4.88 lts. Those values can represent the levels under which the test are considered as reduced. Values which are equal o greater can be considered as "normal" for each one of the parameters studied. The equations of prediction for the SVC, IC, FRC, RV and TLC can be utilized with validity and high confidence to calculate reference static lung volumes in our population (p < 0.00001).

摘要

这些测量肺容量的测试具有显著的适用性,因此有必要经常进行这些测试,这意味着要将肺功能参数的记录值与通过健康人群研究的衍生方程获得的预测值或参考值进行比较。为了推导预测方程,对50名年龄在17至63岁之间的健康男性非吸烟者测量了慢肺活量(SVC)、吸气量(IC)、功能残气量(FRC)、残气量(RV)、肺总量(TLC)以及身体特征。功能测试通过多重呼吸技术和氦稀释法,使用Spinnaker TL肺功能分析仪进行。采用逐步多元回归分析来推导预测肺容量的方程,该方程允许纳入具有统计学显著性(95%置信度)的增加预测的变量,并得出SVC:R = 0.853,标准误(SEE)= 0.350升;IC:R = 0.822,SEE = 0.296升;FRC:R = 0.843,SEE = 0.326升;RV:R = 0.891,SEE = 0.153升;TLC:R = 0.883,SEE = 0.458升。对于估计参数的每个回归模型,方差分析(ANOVA)具有高度显著性(p < 0.00001)。第五百分位数被视为既定容量作为正常值的下限。确定的第五百分位数计算结果为SVC = 3.59升,IC = 2.47升,FRC = 2.14升,RV = 1.26升,TLC = 4.88升。这些值可以代表测试被认为降低的水平。对于所研究的每个参数,等于或大于这些值的可以被视为“正常”。SVC、IC、FRC、RV和TLC的预测方程可以有效且高度置信地用于计算我们人群中的参考静态肺容量(p < 0.00001)。

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