Soygur Haldun, Palaoglu Ozden, Akarsu Eyüp Sabri, Cankurtaran Eylem Sahin, Ozalp Elvan, Turhan Levent, Ayhan Ismail Hakki
Ankara Oncology Training and Research Hospital, Psychiatry Clinic, Ankara, Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1242-7. doi: 10.1016/j.pnpbp.2007.05.001. Epub 2007 May 24.
An association or a casual link has been proposed between the neuroendocrinological and neuroimmunological changes attributed to either depression or cancer. This study investigated whether breast cancer patients with and without major depression exhibit plasma interleukin-6 abnormalities and dexamethasone suppression test results. Four groups, each consisting of 30 women (1--healthy women, 2--patients with major depression, 3--breast cancer patients without major depression, 4--breast cancer patients with major depression), were compared to each other. Psychiatric evaluations were made by structured clinical interview for DSM-IV. Severity of depression was measured with the Hamilton Depression Rating Scale. Plasma levels of interleukin-6 were measured. A dexamethasone suppression test was applied. Breast cancer patients with major depression had markedly higher plasma levels of interleukin-6 than the other group. All breast cancer patients with depression had abnormal dexamethasone suppression test results. These findings suggest a hypothalamo-pituitary-adrenal axis activation and plasma levels of interleukin-6 and plasma interleukin-6 elevation and plasma levels if interleukin-6 and plasma levels of post cortisol concentrations. Evidence for a casual link or association of major depression with immune and endocrinological activation needs to be investigated further.
抑郁症或癌症所导致的神经内分泌和神经免疫变化之间，已有人提出存在关联或因果联系。本研究调查了患有和未患有重度抑郁症的乳腺癌患者是否存在血浆白细胞介素-6异常及地塞米松抑制试验结果。对四组进行了相互比较，每组由30名女性组成（1组——健康女性，2组——重度抑郁症患者，3组——未患重度抑郁症的乳腺癌患者，4组——患有重度抑郁症的乳腺癌患者）。通过针对《精神疾病诊断与统计手册》第四版的结构化临床访谈进行精神科评估。使用汉密尔顿抑郁评定量表测量抑郁严重程度。测量血浆白细胞介素-6水平。进行地塞米松抑制试验。患有重度抑郁症的乳腺癌患者血浆白细胞介素-6水平明显高于其他组。所有患有抑郁症的乳腺癌患者地塞米松抑制试验结果均异常。这些发现提示下丘脑-垂体-肾上腺轴激活以及血浆白细胞介素-6水平升高和血浆皮质醇浓度升高。重度抑郁症与免疫及内分泌激活之间因果联系或关联的证据需要进一步研究。
