Kim Jong-Dae, Kang Seock-Man, Park Mee-Yeon, Jung Tae-Young, Choi Hae-Yun, Ku Sae-Kwang
College of Oriental Medicine, Daegu Haany University, Republic of Korea.
Biosci Biotechnol Biochem. 2007 Jun;71(6):1527-34. doi: 10.1271/bbb.70058.
The preventive anti-diabetic effect of dangnyosoko (DNSK), a Chinese herbal medicine, was evaluated in STZ-induced diabetic rats. DNSK was orally administered once a day from 3 d after STZ-induction at 100, 200, and 500 mg/kg for 4 weeks, and the results were compared to those for glibenclamide. Dramatic decreases in body weight and plasma insulin levels and increases in blood and urine glucose levels were detected in STZ-induced diabetic animals with disruption and disappearance of pancreatic islets and increases in glucagon- and decreases in insulin-producing cells. However, these diabetic changes were significantly and dose-dependently inhibited by treatment with DNSK, and DNSK at 100 mg/kg showed more favorable effects than glibenclamide at 5 mg/kg. Based on these results, it is thought that DNSK has favorable effects in ameliorating changes in blood and urine glucose levels and body weight, and that histopathological changes in the pancreas in STZ induce diabetes.
研究了中药当药索科（DNSK）对链脲佐菌素（STZ）诱导的糖尿病大鼠的预防性抗糖尿病作用。在STZ诱导后第3天起，将DNSK以100、200和500mg/kg的剂量每日口服给药1次，持续4周，并将结果与格列本脲进行比较。在STZ诱导的糖尿病动物中，检测到体重和血浆胰岛素水平显著下降，血糖和尿糖水平升高，胰岛破坏和消失，胰高血糖素分泌细胞增加而胰岛素分泌细胞减少。然而，DNSK治疗可显著且剂量依赖性地抑制这些糖尿病变化，100mg/kg的DNSK比5mg/kg的格列本脲显示出更有利的效果。基于这些结果，认为DNSK在改善血糖和尿糖水平及体重变化方面具有良好作用，且STZ诱导的胰腺组织病理学变化可导致糖尿病。
