Rekha P L, Valluri Vijayalakshmi, Rakh Shilpa S, Pantula Vinod, Ishaq M
Immunogenetics Lab, Department of Genetics, Osmania University, Hyderabad, 500007, India.
J Clin Immunol. 2007 Sep;27(5):486-9. doi: 10.1007/s10875-007-9102-2. Epub 2007 Jun 22.
The present study was designed to analyze the distribution of HLA DQ B1* and DR B1* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1* 05 was found to be decreased in patients' group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1* 03 and DR B1* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1* 05 is observed to be negatively correlated with this thyroid dysfunction. Since the disease-susceptible HLA class II alleles appear to differ in various ethnic groups for some autoimmune diseases, the observed association from Indian series of patients holds significance.
本研究旨在分析来自印度海得拉巴的甲状腺肿性青少年自身免疫性甲状腺功能减退症患者中HLA DQ B1和DR B1的分布情况。分析表明，与对照组相比，该组患者中HLA DQ B1* 03等位基因频率增加（P < 0.000），HLA DR B1* 04等位基因频率增加（P < 0.05），而与对照组相比，患者组中DQB1* 05频率降低（p < 0.01）。总之，我们报告DQ B1* 03和DR B1* 04与甲状腺肿性青少年自身免疫性甲状腺功能减退症呈正相关，而DQB1* 05与这种甲状腺功能障碍呈负相关。由于某些自身免疫性疾病的疾病易感性HLA II类等位基因在不同种族群体中似乎有所不同，因此从印度患者系列中观察到的关联具有重要意义。
