拉脱维亚青少年类风湿关节炎患者的人类白细胞抗原II类基因

HLA class II genes in Latvian patients with juvenile rheumatoid arthritis.

作者信息

Rumba I, Denisova A, Sochnev A, Nilsson B, Sanjeevi C B

机构信息

Clinic of Pediatrics, Medical Academy of Latvia, Riga, Latvia.

出版信息

Tissue Antigens. 1997 Jan;49(1):56-60. doi: 10.1111/j.1399-0039.1997.tb02711.x.

DOI:10.1111/j.1399-0039.1997.tb02711.x

PMID:9027967

Abstract

PCR-based HLA genotyping was used to analyze the association of HLA-DR and -DQ genes in 127 juvenile rheumatoid arthritis patients and 111 population-based controls from Latvia. The results show DQA103 to be positively associated in overall patients and DRB101-DQA10101-DQB10501 to be negatively associated with JRA in overall patients and in polyarthritis patients compared to controls. These data indicate the immunogenetic heterogeneity in the JRA patients, in the disease subgroups and in different ethnic groups. Rheumatoid factor (RF) was assayed in patients (n = 119) and controls (n = 98). RF was present in patients (7/119, 6%) compared to controls (5/98, 5%). None of the DQA1, DQB1 alleles, DQ and DR-DQ haplotypes was associated in seropositive patients compared to seropositive controls. DR1-DQ5 (DQA10101-B0501) was decreased in seronegative patients (11/111, 10%) compared to seronegative controls (24/105, 23%), but the difference was not significant after correction of the p value.

摘要

采用基于聚合酶链反应（PCR）的人类白细胞抗原（HLA）基因分型技术，分析了127例拉脱维亚青少年类风湿性关节炎患者及111例基于人群的对照者中HLA - DR和 - DQ基因的关联性。结果显示，在总体患者中DQA103呈正相关，而在总体患者及多关节炎患者中，与对照组相比，DRB101 - DQA10101 - DQB10501与青少年类风湿性关节炎呈负相关。这些数据表明青少年类风湿性关节炎患者、疾病亚组及不同种族人群中存在免疫遗传异质性。对119例患者及98例对照者检测了类风湿因子（RF）。患者中RF阳性率为7/119（6%），对照者中为5/98（5%）。与血清学阳性对照者相比，血清学阳性患者中DQA1、DQB1等位基因、DQ及DR - DQ单倍型均无相关性。与血清学阴性对照者（24/105，23%）相比，血清学阴性患者中DR1 - DQ5（DQA10101 - B0501）比例降低（11/111，10%），但校正P值后差异无统计学意义。