中国肝癌和肺癌患者的生活质量作为癌症生存的预测指标

Quality of life as a predictor of cancer survival among Chinese liver and lung cancer patients.

作者信息

Fielding Richard, Wong Wing S

机构信息

Department of Community Medicine, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 5/F William M.W. Mong Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong.

出版信息

Eur J Cancer. 2007 Jul;43(11):1723-30. doi: 10.1016/j.ejca.2007.05.002. Epub 2007 Jun 27.

DOI:10.1016/j.ejca.2007.05.002

PMID:17588741

Abstract

The utility of quality of life (QoL) scores in predicting cancer survival remains inconclusive because of methodological and/or statistical heterogeneity. We examined whether QoL scores predicted survival among Chinese liver (n=176) and lung cancer (n=358) patients. Cox proportional hazards models examined if QoL and psychosocial variables predicted survival after fully adjusting for sociodemographic and clinical factors. The results showed that global QoL scores did not predict survival in either patient group. Less advanced cancer stage (HR=2.574, p<0.05) was associated with longer survival in liver cancer. Longer survival in lung cancer was predicted by younger age (HR=1.016, p<0.05), less advanced cancer stage (HR=1.978, p<0.001), having had treatment before baseline (HR=0.671, p<0.05), better physical well-being (HR=0.941, p<0.001) and better appetite (HR=0.888, p<0.001). Global QoL (FACT-G(Ch)) scores do not predict survival in Chinese liver and lung cancer patients. QoL physical well-being subscale predicted lung cancer survival.

摘要

由于方法学和/或统计学上的异质性，生活质量（QoL）评分在预测癌症生存率方面的效用仍无定论。我们研究了QoL评分是否能预测中国肝癌患者（n = 176）和肺癌患者（n = 358）的生存率。Cox比例风险模型在对社会人口统计学和临床因素进行充分调整后，检验了QoL和心理社会变量是否能预测生存率。结果显示，整体QoL评分在两组患者中均不能预测生存率。肝癌患者中，癌症分期较晚（HR = 2.574，p < 0.05）与较短生存期相关。肺癌患者中，年龄较小（HR = 1.016，p < 0.05）、癌症分期较晚（HR = 1.978，p < 0.001）、在基线前接受过治疗（HR = 0.671，p < 0.05）、身体状况较好（HR = 0.941，p < 0.001）和食欲较好（HR = 0.888，p < 0.001）可预测生存期较长。整体QoL（FACT-G(Ch)）评分不能预测中国肝癌和肺癌患者的生存率。QoL身体状况子量表可预测肺癌生存率。