Clementz B A, Sweeney J A, Hirt M, Haas G
University of Minnesota.
Psychophysiology. 1991 Sep;28(5):570-8. doi: 10.1111/j.1469-8986.1991.tb01995.x.
Abnormalities of visual pursuit tracking are frequent in the first-degree relatives of probands with schizophrenia. The relationship between oculomotor abnormalities and schizophrenia-related characteristics in those family members, however, has received little attention. Fifty-three first-degree relatives of 24 probands with schizophrenia were evaluated for the presence of schizophrenia-related characteristics using both interview (Schedule for Schizotypal Personalities) and questionnaire (Chapman scales). The family members also had their eye movements recorded during pursuit tracking tasks and scored for gain in both the frequency and time domains, and saccadic intrusions. Social-interpersonal schizophrenia-related features were significantly related to both time- and frequency-domain gain calculations. It appears that abnormalities in the smooth-pursuit oculomotor system may be associated with symptoms conjectured to be most closely related to a genetic diathesis for schizophrenia. These findings provide further evidence that oculomotor abnormalities may be related to risk for this disorder.
精神分裂症先证者的一级亲属中视觉追踪异常很常见。然而，这些家庭成员中眼动异常与精神分裂症相关特征之间的关系却很少受到关注。对24名精神分裂症先证者的53名一级亲属进行了评估，通过访谈（分裂型人格量表）和问卷（查普曼量表）来确定是否存在精神分裂症相关特征。这些家庭成员在追踪任务期间也进行了眼动记录，并在频率和时间域对增益以及扫视侵入进行评分。与精神分裂症相关的社会人际特征与时间域和频率域的增益计算均显著相关。看来平稳追踪眼动系统的异常可能与推测与精神分裂症遗传素质最密切相关的症状有关。这些发现进一步证明眼动异常可能与该疾病的风险有关。
