Clementz B A, Sweeney J A, Hirt M, Haas G
Laboratory of Clinical Psychophysiology, New York Hospital-Cornell University Medical College.
J Abnorm Psychol. 1990 Nov;99(4):327-35. doi: 10.1037//0021-843x.99.4.327.
Oculomotor functioning of 26 probands with schizophrenia, 12 spectrum and 46 nonspectrum first-degree relatives, and 38 nonpsychiatric control subjects was evaluated. Spectrum relatives had more anticipatory saccades (ASs) and lower pursuit gain than nonspectrum relatives, who had more ASs and lower pursuit gain than control subjects. Probands also had lower pursuit gain than nonspectrum relatives and control subjects but did not differ from other groups on AS frequency. Control subjects had more globally accurate pursuit tracking (root mean square [RMS] error deviation) than both relative groups, whereas probands had the poorest RMS scores. Square wave jerk frequency did not differentiate the groups. Attention enhancement affected the frequency of ASs but did not affect either the other intrusive saccadic event or RMS scores. These results offer evidence that eye-movement dysfunction may serve as a biological marker for schizophrenia.
对26名精神分裂症先证者、12名谱系和46名非谱系一级亲属以及38名非精神科对照受试者的动眼功能进行了评估。谱系亲属比非谱系亲属有更多的预期性扫视（ASs）和更低的追踪增益，而非谱系亲属比对照受试者有更多的ASs和更低的追踪增益。先证者的追踪增益也比非谱系亲属和对照受试者低，但在AS频率上与其他组没有差异。对照受试者比两个亲属组有更全局准确的追踪跟踪（均方根[RMS]误差偏差），而先证者的RMS得分最差。方波急跳频率没有区分这些组。注意力增强影响了ASs的频率，但既不影响其他侵入性扫视事件，也不影响RMS得分。这些结果提供了证据，表明眼球运动功能障碍可能是精神分裂症的生物学标志物。
