Hutton S, Kennard C
Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, United Kingdom.
Neurology. 1998 Mar;50(3):604-9. doi: 10.1212/wnl.50.3.604.
Oculomotor abnormalities, particularly in smooth pursuit tracking, are one of the most widely investigated biological markers of schizophrenia. However, despite the wealth of published data, important questions concerning the exact nature of these abnormalities remain unanswered. Many of the studies use unreliable methodology, and few attempts have been made to interpret the observed oculomotor dysfunction in terms of current understanding of eye movement physiology. Also, the potential effects of antipsychotic medication have been poorly addressed. Recent research, using more reliable measurement techniques and novel saccadic paradigms are producing important results and may provide a more productive framework for future studies of oculomotor abnormalities in schizophrenia.
动眼神经异常，尤其是在平稳跟踪追踪方面，是精神分裂症研究最为广泛的生物学标志物之一。然而，尽管已发表的数据丰富，但关于这些异常的确切性质的重要问题仍未得到解答。许多研究采用了不可靠的方法，而且很少有人尝试根据目前对眼球运动生理学的理解来解释观察到的动眼神经功能障碍。此外，抗精神病药物的潜在影响也未得到充分探讨。最近的研究使用了更可靠的测量技术和新颖的扫视范式，正在产生重要成果，并可能为未来精神分裂症动眼神经异常的研究提供一个更有成效的框架。
