Canakci Varol, Canakci Cenk Fatih, Yildirim Abdulkadir, Ingec Metin, Eltas Abubekir, Erturk Ayşe
Department of Periodontology, School of Dentistry, Atatürk University, Erzurum, Turkey.
J Clin Periodontol. 2007 Aug;34(8):639-45. doi: 10.1111/j.1600-051X.2007.01105.x. Epub 2007 Jun 21.
To evaluate the possible link between the severity of periodontal disease and pre-eclampsia and to correlate this link to clinical periodontal parameters and interleukin (IL)-1beta, tumour necrosis factor-alpha (TNF-alpha), and prostaglandins (PGE(2)) levels in both gingival crevicular fluid (GCF) and serum.
Fifty-nine pregnant women (20 mild pre-eclampsia, 18 severe pre-eclampsia, and 21 healthy pregnant women) were included in the study. Dental and periodontal recordings as well as GCF and blood samples were obtained within 48 h preceding delivery.
The results of multivariate logistic regression showed a highly significant association between mild to severe pre-eclampsia and severe periodontal disease (p<0.001). After adjusting for potential confounders (smoking, body weight, socioeconomic status, education level, and age), severe pre-eclamptic women were 3.78 (1.77-12.74) times more likely to present severe periodontal disease than normotensive pregnant women. This odds ratio (OR) was 2.43 (1.13-8.19) for mild pre-eclamptic women. IL-1beta, TNF-alpha, and PGE(2) levels in both serum and GCF were also significantly higher in the pre-eclamptic groups than the normotensive women.
These results indicate that the presence and severity of periodontal disease seems to increase the risk for not only the occurrence but also the severity of pre-eclampsia in pregnant women.
评估牙周疾病严重程度与子痫前期之间的可能联系，并将此联系与龈沟液（GCF）和血清中的临床牙周参数、白细胞介素（IL）-1β、肿瘤坏死因子-α（TNF-α）及前列腺素（PGE₂）水平相关联。
本研究纳入了59名孕妇（20名单纯性轻度子痫前期患者、18名重度子痫前期患者以及21名健康孕妇）。在分娩前48小时内获取牙科及牙周记录以及GCF和血液样本。
多因素逻辑回归结果显示，轻度至重度子痫前期与重度牙周疾病之间存在高度显著关联（p<0.001）。在对潜在混杂因素（吸烟、体重、社会经济地位、教育水平和年龄）进行校正后，重度子痫前期孕妇患重度牙周疾病的可能性是血压正常孕妇的3.78（1.77 - 12.74）倍。轻度子痫前期孕妇的这一比值比（OR）为2.43（1.13 - 8.19）。子痫前期组血清和GCF中的IL-1β、TNF-α及PGE₂水平也显著高于血压正常的女性。
这些结果表明，牙周疾病的存在及其严重程度似乎不仅增加了孕妇发生子痫前期的风险，还增加了子痫前期的严重程度。
