Kunnen Alina, Blaauw Judith, van Doormaal Jasper J, van Pampus Maria G, van der Schans Cees P, Aarnoudse Jan G, van Winkelhoff Arie J, Abbas Frank
Department of Periodontology, Academic Center for Oral Health, University Medical Center Groningen, Groningen, The Netherlands.
J Clin Periodontol. 2007 Mar;34(3):202-7. doi: 10.1111/j.1600-051X.2006.01036.x.
Pre-eclampsia is a complication of pregnancy characterized by systemic vascular dysfunction and pathological changes in placental arteries. Growing evidence of chronic infection as an aetiological factor in vascular diseases prompted us to study maternal periodontal disease in subjects with early-onset pre-eclampsia (<34 weeks).
A case-control study was carried out on 17 early-onset pre-eclamptic women and 35 controls with uncomplicated pregnancies in a period of 3-28 months postpartum. All were Caucasians. Full-mouth periodontal examinations were performed to determine the periodontal condition. Subgingival-plaque samples were analysed by anaerobic culture techniques for the presence of seven bacterial periodontal pathogens. Potential confounders as age, smoking, educational level and body mass index were determined.
Severe periodontal disease was found in 82% of the pre-eclamptic and in 37% of the control group (p=0.009). After adjusting for age, smoking and educational level, the odds ratio was 7.9 (95% CI: 1.9-32.8). The periodontopathic microorganism Micromonas micros was more prevalent in the case group (p=0.040) while Campylobacter rectus was more prevalent in the control group (p=0.047).
These results indicate that Caucasian women with a recent history of early-onset pre-eclampsia have a worse periodontal condition, as compared with women with uncomplicated deliveries.
子痫前期是一种妊娠并发症，其特征为全身血管功能障碍和胎盘动脉的病理变化。越来越多的证据表明慢性感染是血管疾病的病因之一，这促使我们研究早发型子痫前期（<34周）患者的母体牙周疾病。
对17例早发型子痫前期妇女和35例产后3 - 28个月妊娠结局正常的对照者进行病例对照研究。所有研究对象均为白种人。进行全口牙周检查以确定牙周状况。采用厌氧培养技术分析龈下菌斑样本中7种牙周病原菌的存在情况。确定年龄、吸烟、教育程度和体重指数等潜在混杂因素。
子痫前期组82%的患者患有严重牙周疾病，对照组这一比例为37%（p = 0.009）。在对年龄、吸烟和教育程度进行校正后，比值比为7.9（95%可信区间：1.9 - 32.8）。病例组中牙周病原菌微小微单胞菌更为常见（p = 0.040），而对照组中直肠弯曲菌更为常见（p = 0.047）。
这些结果表明，与分娩结局正常的妇女相比，近期有早发型子痫前期病史的白种妇女牙周状况更差。
