Lu Hsueh-Chieh, Yang Ying-Ying, Huang Yu-Lin, Chen Te-Li, Chuang Chiao-Lin, Lee Fa-Yauh, Lee Shou-Dong
Department of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
J Chin Med Assoc. 2007 Jun;70(6):249-52. doi: 10.1016/S1726-4901(09)70368-5.
Infection with Cryptococcus neoformans often occurs in immunocompromised hosts. It is usually acquired by invasion of the respiratory tract, and then the organisms may spread hematogenously to other viscera, mainly the central nervous system. Although there are some reports of primary cutaneous cryptococcosis, cryptococcal skin disease is a rare feature of disseminated cryptococcosis, and has a poor outcome if unrecognized and untreated. We present a case of cryptococcal cellulitis in a patient with rheumatoid arthritis who was receiving long-term steroid treatment. Reviewing the literature, this is the first report of rheumatoid arthritis with disseminated cryptococcosis initially presenting as cellulitis.
新型隐球菌感染常发生于免疫功能低下的宿主。通常通过呼吸道侵入而感染，随后病原体可能经血行播散至其他内脏，主要是中枢神经系统。虽然有一些原发性皮肤隐球菌病的报道，但隐球菌性皮肤病是播散性隐球菌病的罕见表现，如果未被识别和治疗，预后较差。我们报告一例类风湿关节炎患者在接受长期类固醇治疗时发生隐球菌性蜂窝织炎的病例。查阅文献发现，这是首例类风湿关节炎合并播散性隐球菌病最初表现为蜂窝织炎的报告。
