Ablashi D V, Easton J M
Cancer Res. 1976 Feb;36(2 pt 2):701-3.
In this paper we discuss the use of Herpesvirus saimiri as a model for the development of vaccines against herpesvirus-induced neoplasia in primates. Attempts at protection against the oncogenicity of H. saimiri have centered on the inactivation of virus by heat and formalin, the production of temperature-sensitive H. saimiri mutants, and the attenuation of the virus. Each of these approaches has provided information of use in the development of vaccines that may possibly be used in man.
在本文中，我们讨论了将松鼠猴疱疹病毒用作开发预防灵长类动物疱疹病毒诱导肿瘤的疫苗的模型。针对松鼠猴疱疹病毒致癌性的防护尝试主要集中在通过加热和福尔马林使病毒失活、制备温度敏感的松鼠猴疱疹病毒突变体以及使病毒减毒。这些方法中的每一种都为开发可能用于人类的疫苗提供了有用的信息。
