Akyol-Salman Ilknur, Leçe-Sertöz Deniz, Baykal Orhan
Department of Ophthalmology, Atatürk University Faculty of Medicine, Erzurum, Turkey.
J Ocul Pharmacol Ther. 2007 Jun;23(3):280-3. doi: 10.1089/jop.2006.108.
To compare the anti-inflammatory and analgesic effects of topical pranoprofen 0.1% with diclofenac sodium 0.1% after strabismus surgery, 40 patients were prospectively randomized and assigned into 2 groups. Signs and symptoms of inflammation, as well as intraocular pressure (IOP) of patients, were evaluated at 1 day and 1 and 3 weeks following surgery. Both groups reported reduced inflammation and discomfort at 1 week, as compared to 1 day. There was no statistically significant difference in any measurement of postoperative inflammation (i.e., discomfort, chemosis, secretion, conjunctival hyperemia, and conjunctival gap size) between the 2 groups at any time. None of the patients developed an allergic reaction to the medications and IOP measurements were within the normal limits in both groups. Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery.
为比较0.1%普拉洛芬滴眼液与0.1%双氯芬酸钠滴眼液在斜视手术后的抗炎和镇痛效果，将40例患者前瞻性随机分为2组。在术后1天、1周和3周评估患者的炎症体征和症状以及眼压（IOP）。与术后1天相比，两组患者在术后1周时炎症和不适均减轻。两组在术后任何时间的炎症指标（即不适、球结膜水肿、分泌物、结膜充血和结膜伤口大小）测量上均无统计学显著差异。两组患者均未出现药物过敏反应，眼压测量均在正常范围内。结果发现，0.1%普拉洛芬滴眼液在减轻斜视手术后的炎症和疼痛方面与0.1%双氯芬酸钠滴眼液效果相当。普拉洛芬可作为治疗斜视手术后炎症的一种安全有效的抗炎替代药物。
