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儿童斜视手术后普拉洛芬的应用

Use of Pranoprofen After Strabismus Surgery in Children.

作者信息

Pawłowski Wojciech, Urban Beata, Zawistowska Joanna, Bakunowicz-Łazarczyk Alina

机构信息

Department of Paediatric Ophthalmology and Strabismus, Medical University of Bialystok, ul. Waszyngtona 17, 15-274 Bialystok, Poland.

出版信息

J Clin Med. 2025 Mar 19;14(6):2104. doi: 10.3390/jcm14062104.

DOI:10.3390/jcm14062104
PMID:40142912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943285/
Abstract

: The aim of our study is to evaluate the efficacy of pranoprofen 0.1% in preventing the occurrence of postoperative complications, including postoperative ocular inflammation after strabismus surgery in children. 90 children operated on for strabismus in the Department of Paediatric Ophthalmology and Strabismus of the Medical University of Bialystok between 2022 and 2023 were included in the study. The patients were aged from 2 to 17 years old. Patients were divided into three groups of 30 patients according to the method of topical postoperative treatment (group I: tobramycin, pranoprofen, dexpanthenol; group II: tobramycin, dexamethasone, dexpanthenol; group III: tobramycin, pranoprofen, dexamethasone, dexpanthenol). Patients were followed up the day after surgery, on postoperative day 14 and then 3 months after surgery. : No child showed signs of postoperative infection. There was one case of allergic reaction each in groups I and III. Most complications were present in group II (six cases: there were allergic reactions that occurred in three patients. Two patients experienced a complication in the form of delle, while one patient developed a granuloma), which was a statistically significant difference compared to groups I and III ( = 0.032). : Pranoprofen used postoperatively is as effective as a glucocorticosteroid, and from our observations, carries fewer complications in cases requiring prolonged use of the anti-inflammatory treatment. Systematic postoperative follow-up is essential for the diagnosis and possible management of postsurgical complications.

摘要

我们研究的目的是评估0.1%的普拉洛芬在预防术后并发症发生方面的疗效,这些并发症包括儿童斜视手术后的眼部炎症。2022年至2023年期间,在比亚韦斯托克医科大学小儿眼科与斜视科接受斜视手术的90名儿童被纳入该研究。患者年龄在2至17岁之间。根据术后局部治疗方法,患者被分为三组,每组30人(第一组:妥布霉素、普拉洛芬、泛醇;第二组:妥布霉素、地塞米松、泛醇;第三组:妥布霉素、普拉洛芬、地塞米松、泛醇)。术后第一天、术后第14天以及术后3个月对患者进行随访。:没有儿童出现术后感染迹象。第一组和第三组各有1例过敏反应。大多数并发症出现在第二组(6例:3名患者出现过敏反应。2名患者出现了角膜上皮剥脱形式的并发症,1名患者出现了肉芽肿),与第一组和第三组相比,这具有统计学显著差异(P = 0.032)。:术后使用的普拉洛芬与糖皮质激素一样有效,并且根据我们的观察,在需要长期使用抗炎治疗的情况下,其并发症较少。术后系统随访对于诊断和处理术后并发症至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c3d/11943285/d825175f4f18/jcm-14-02104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c3d/11943285/d825175f4f18/jcm-14-02104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c3d/11943285/d825175f4f18/jcm-14-02104-g001.jpg

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本文引用的文献

1
Effect of Prophylactic Topical Antibiotics on Rates of Infectious Complications After Strabismus Surgery: A Large Database Study.预防性局部应用抗生素对斜视手术后感染性并发症发生率的影响:一项大型数据库研究
Am J Ophthalmol. 2025 Mar;271:299-303. doi: 10.1016/j.ajo.2024.12.005. Epub 2024 Dec 10.
2
Severe conjunctival allergic reaction to polyglactin 910 sutures following strabismus surgery: A case report.斜视手术后对聚乙醇酸910缝线的严重结膜过敏反应:一例报告。
Int J Surg Case Rep. 2024 Sep;122:110168. doi: 10.1016/j.ijscr.2024.110168. Epub 2024 Aug 13.
3
Effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone and pranoprofen eye drops in the treatment of dry eye after phacoemulsification.
玻璃酸钠滴眼液联合妥布霉素、地塞米松和普拉洛芬滴眼液治疗白内障超声乳化术后干眼症的效果。
Indian J Ophthalmol. 2022 Dec;70(12):4319-4324. doi: 10.4103/ijo.IJO_1652_22.
4
Incidence of infectious complications following strabismus surgery.斜视手术后感染性并发症的发生率。
J AAPOS. 2022 Jun;26(3):158-160. doi: 10.1016/j.jaapos.2022.01.006. Epub 2022 Apr 15.
5
Effect of a Topical Nonsteroidal Anti-Inflammatory Drug (0.1% Pranoprofen) on VEGF and COX-2 Expression in Primary Pterygium.局部用非甾体抗炎药(0.1% 普拉洛芬)对原发性翼状胬肉中血管内皮生长因子(VEGF)和环氧合酶 -2(COX-2)表达的影响
Front Pharmacol. 2021 Jul 9;12:709251. doi: 10.3389/fphar.2021.709251. eCollection 2021.
6
The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns.普拉洛芬在小鼠角膜碱烧伤模型中的治疗作用及可能机制
J Ophthalmol. 2020 Apr 6;2020:7485912. doi: 10.1155/2020/7485912. eCollection 2020.
7
Strabismus Surgery Infection Prophylaxis and Timing of First Postoperative Visit.斜视手术感染预防及术后首次复诊时间
J Pediatr Ophthalmol Strabismus. 2019 Nov 1;56(6):354-359. doi: 10.3928/01913913-20190808-01.
8
Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery.普拉洛芬对第二眼白内障手术中房水单核细胞趋化蛋白-1水平及疼痛缓解的影响。
Front Pharmacol. 2018 Jul 17;9:783. doi: 10.3389/fphar.2018.00783. eCollection 2018.
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The Toxicity of Nonsteroidal Anti-inflammatory Eye Drops against Human Corneal Epithelial Cells in Vitro.非甾体类抗炎眼药水对人角膜上皮细胞的体外毒性研究
J Korean Med Sci. 2015 Dec;30(12):1856-64. doi: 10.3346/jkms.2015.30.12.1856. Epub 2015 Nov 30.
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Effect of a topical nonsteroidal anti-inflammatory agent (0.1 % pranoprofen) on acute central serous chorioretinopathy.一种局部用非甾体抗炎药(0.1% 普拉洛芬)对急性中心性浆液性脉络膜视网膜病变的影响。
Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1489-1496. doi: 10.1007/s00417-015-3215-8. Epub 2015 Nov 9.