Alchaghouri Samir, Wong Kenneth Y K, Perry Raphael A, Ramsdale David R, Somauroo John D, Pyatt Jason R
Cardiology Department, Royal Liverpool University Hospital, Liverpool, UK.
Ann Noninvasive Electrocardiol. 2007 Apr;12(2):104-10. doi: 10.1111/j.1542-474X.2007.00148.x.
QT peak prolongation is associated with left ventricular hypertrophy (LVH) in patients with hypertension. This study tests the hypothesis that QT peak prolongation correlates with LV mass index in apparently healthy young football players.
QT peak and other ECG criteria for LVH were assessed in 117 male professional footballers (mean age 16.4 years +/- SD 0.76). Their left ventricular mass index (LVMI) was assessed by transthoracic echocardiography. Heart rate-corrected QT peak (QTpc) interval was measured in lead I using Bazett's formula. Spearman (2-tailed) test and UNIANOVA was used to assess if there were correlations between QT peak and the various echocardiographic and ECG indices of LVH.
Echocardiographic LVH, defined as LVMI > or = 134 g/m(2), was seen in 79 (70.5%) subjects. ECG-defined LVH was present in 54 (50 %) players by Sokolow-Lyon criteria, in 19 (16 %) players by Romhilt Score, in 5 (4 %) players by Cornell voltage criteria, and in 7 (6 %) players by Cornell product >2436 mm ms. There was no correlation between QT peak (QTpc) and LVMI on echocardiography (Spearman r = 0.058, 2-tailed P = 0.54). In addition, there was no relation between LVH and QTpc of lead I using any of the following ECG criteria: Sokolow-Lyon (P = 0.6), Romhilt (P = 0.3), Cornell voltage (P = 0.8), or Cornell product (P = 0.6).
QT peak interval, which is associated with pathological LVH in hypertensive patients and is a measure of risk of cardiac death, does not correlate with LVH characterized by myocyte hypertrophy in young apparently healthy professional footballers.
高血压患者的QT峰延长与左心室肥厚（LVH）相关。本研究检验以下假设：在看似健康的年轻足球运动员中，QT峰延长与左心室质量指数相关。
对117名男性职业足球运动员（平均年龄16.4岁±标准差0.76）的QT峰及其他左心室肥厚的心电图标准进行评估。通过经胸超声心动图评估他们的左心室质量指数（LVMI）。使用Bazett公式在I导联测量心率校正的QT峰（QTpc）间期。采用Spearman（双侧）检验和单因素方差分析来评估QT峰与左心室肥厚的各种超声心动图和心电图指标之间是否存在相关性。
79名（70.5%）受试者出现超声心动图定义的左心室肥厚，即LVMI≥134 g/m²。根据Sokolow-Lyon标准，54名（50%）运动员存在心电图定义的左心室肥厚；根据Romhilt评分，19名（16%）运动员存在；根据Cornell电压标准，5名（4%）运动员存在；根据Cornell乘积>2436 mm ms，7名（6%）运动员存在。超声心动图上QT峰（QTpc）与LVMI之间无相关性（Spearman r = 0.058，双侧P = 0.54）。此外，使用以下任何一种心电图标准，I导联的左心室肥厚与QTpc之间均无关联：Sokolow-Lyon（P = 0.6）、Romhilt（P = 0.3）、Cornell电压（P = 0.8）或Cornell乘积（P = 0.6）。
QT峰间期在高血压患者中与病理性左心室肥厚相关，是心脏死亡风险的一种度量，但在看似健康的年轻职业足球运动员中，与以心肌细胞肥厚为特征的心左心室肥厚无关。
