Jäger T, Szarvas T, vom Dorp F, Börgermann C, Schenck M, Schmid K W, Rübben H
Klinik für Urologie, Universitätsklinikum, Hufelandstrasse 55, 45147 Essen.
Urologe A. 2007 Sep;46(9):1152-6. doi: 10.1007/s00120-007-1429-z.
The protein structure of human tumor tissue has a significant influence on the molecular attributes. It was demonstrated that the individual prognosis of tumor patients is among other things dependent on molecular tumor tissue characteristics.A promising marker is E-cadherin, an adhesion glycoprotein which plays a central role in the mediation of cell-cell contacts. Aberrant E-cadherin expressions were described in several tumors such as in bladder cancer. This was also found to be correlated with tumor invasion and survival. There are hardly any fast, quantitative and easily automated protein assays in everyday practice which can analyze several markers at the same time. With silicon chip technology we have a new detection and measurement method which makes it possible to give a quantitative analysis of numerous different proteins in tissue, urine, or serum in a few minutes.
人类肿瘤组织的蛋白质结构对分子属性有重大影响。已证明肿瘤患者的个体预后在其他方面取决于肿瘤组织的分子特征。一个有前景的标志物是E-钙黏蛋白，一种在细胞间接触介导中起核心作用的黏附糖蛋白。在几种肿瘤如膀胱癌中描述了E-钙黏蛋白的异常表达。这也被发现与肿瘤侵袭和生存相关。在日常实践中几乎没有任何快速、定量且易于自动化的蛋白质检测方法能够同时分析多种标志物。借助硅芯片技术，我们有了一种新的检测和测量方法，它能够在几分钟内对组织、尿液或血清中的多种不同蛋白质进行定量分析。
