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介孔二氧化硅纳米材料:用于癌症诊疗及药物与基因递送的多功能纳米载体

Mesoporous Silica Nanomaterials: Versatile Nanocarriers for Cancer Theranostics and Drug and Gene Delivery.

作者信息

Kesse Samuel, Boakye-Yiadom Kofi Oti, Ochete Belynda Owoya, Opoku-Damoah Yaw, Akhtar Fahad, Filli Mensura Sied, Asim Farooq Muhammad, Aquib Md, Maviah Mily Bazezy Joelle, Murtaza Ghulam, Wang Bo

机构信息

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

出版信息

Pharmaceutics. 2019 Feb 13;11(2):77. doi: 10.3390/pharmaceutics11020077.

Abstract

Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loading competence. Mesoporous silica nanoparticles (MSNPs) show a very high loading capacity for therapeutic agents. It is well known that cancer is one of the most severe known medical conditions, characterized by cells that grow and spread rapidly. Thus, curtailing cancer is one of the greatest current challenges for scientists. Nanotechnology is an evolving field of study, encompassing medicine, engineering, and science, and it has evolved over the years with respect to cancer therapy. This review outlines the applications of mesoporous nanomaterials in the field of cancer theranostics, as well as drug and gene delivery. MSNs employed as therapeutic agents, as well as their importance and future prospects in the ensuing generation of cancer theranostics and drug and therapeutic gene delivery, are discussed herein. Thus, the use of mesoporous silica nanomaterials can be seen as using one stone to kill three birds.

摘要

介孔二氧化硅纳米材料(MSNs)已取得显著成就,因其光学透明特性、灵活的尺寸、功能性表面、低毒性以及良好的药物负载能力,被研究人员视为可在癌症治疗、基因递送和药物递送方面带来重大变革的材料。介孔二氧化硅纳米颗粒(MSNPs)对治疗剂显示出非常高的负载能力。众所周知,癌症是已知最严重的病症之一,其特征是细胞生长和扩散迅速。因此,遏制癌症是科学家当前面临的最大挑战之一。纳米技术是一个不断发展的研究领域,涵盖医学、工程和科学,多年来在癌症治疗方面不断演进。本综述概述了介孔纳米材料在癌症诊疗、药物和基因递送领域的应用。本文讨论了用作治疗剂的MSNs及其在下一代癌症诊疗以及药物和治疗性基因递送中的重要性和未来前景。因此,使用介孔二氧化硅纳米材料可被视为一石三鸟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3df/6410079/1c0930ecf0ca/pharmaceutics-11-00077-g001.jpg

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