Inomata Koichi, Shinoda Kei, Ohde Hisao, Tsunoda Kazushige, Hanazono Gen, Kimura Itaru, Yuzawa Mitsuko, Tsubota Kazuo, Miyake Yozo
Laboratory of Visual Physiology, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.
Graefes Arch Clin Exp Ophthalmol. 2007 Dec;245(12):1773-80. doi: 10.1007/s00417-007-0610-9. Epub 2007 Jun 26.
To report the outcome of transcorneal electrical stimulation (TES) of the visual system on long-standing retinal artery occlusion (RAO).
Open labeled, case series.
Two patients with central RAO (15 and 33 months respectively) and one with branch RAO (26 months) underwent TES therapy. Subjective and objective ophthalmological evaluations were performed before and after the TES. The ages of the patients were 38, 49, and 63 years. The TES (20 Hz biphasic pulses, 30 minutes, up to 1100 uA) was delivered by a bipolar contact lens electrode once a month for 3 months. Perimetric and/or electrophysiological examinations were performed as outcome measures.
The visual acuity improved by more than 0.2 logMAR units in two cases, and the visual fields were improved in all three cases. The multifocal ERGs which had been reduced in the loci corresponding to the ischemic retinal area were improved after the treatment in two cases. Neither ocular nor systemic adverse effects were observed except for transient superficial keratitis.
TES of the retina can improve retinal function in eyes with long-standing RAOs.
报告经角膜电刺激（TES）视觉系统治疗长期视网膜动脉阻塞（RAO）的结果。
开放标签病例系列。
两名中心性RAO患者（分别为15个月和33个月病程）和一名分支性RAO患者（26个月病程）接受了TES治疗。在TES治疗前后进行了主观和客观的眼科评估。患者年龄分别为38岁、49岁和63岁。通过双极隐形眼镜电极给予TES（20赫兹双相脉冲，30分钟，最高1100微安），每月一次，共3个月。以视野检查和/或电生理检查作为疗效指标。
两例患者的视力提高超过0.2 logMAR单位，三例患者的视野均有改善。两例患者治疗后，对应缺血性视网膜区域的多焦视网膜电图降低部位有所改善。除了短暂的浅层角膜炎外，未观察到眼部或全身不良反应。
视网膜的TES可改善长期RAO患者的视网膜功能。
