Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Graefes Arch Clin Exp Ophthalmol. 2013 Jul;251(7):1867-70. doi: 10.1007/s00417-013-2341-4. Epub 2013 Apr 19.
To report an improvement of the visual acuity after transcorneal electrical stimulation (TES) in a case of Best vitelliform macular dystrophy (BVMD).
A 26-year-old woman diagnosed with BVMD presented with reduced vision. Her best corrected visual acuity (BCVA) was reduced to 20/200 in the right eye, and TES was performed once a month for two sessions. The current of the biphasic pulses (anodic first; duration, 10 msec; frequency, 20 Hz) was delivered using a DTL-electrode, and the duration of the TES was 30 min.
The BCVA in the right eye slowly improved after the TES, and 6 months later the BCVA was 20/25. The results of Humphrey visual field tests (VF) and multifocal ERGs (mfERGs) were only slightly changed. Two years later, the BCVA decreased, and it was improved again after another session of TES with the same parameters of the electrical pulses.
The improvement of the visual acuity in our case of BVMD indicates that TES should be tried in other cases of retinal dystrophy. Further clinical and laboratory studies on TES are needed.
报告一例经角膜电刺激(TES)治疗后最佳型类维生素 A 黄斑营养不良(BVMD)患者视力提高的情况。
一名 26 岁女性被诊断为 BVMD,出现视力下降。右眼最佳矫正视力(BCVA)降至 20/200,每月进行 TES 治疗一次,共两次。双相脉冲(阳极首先;持续时间 10 毫秒;频率 20 Hz)使用 DTL 电极传递,TES 持续 30 分钟。
右眼 BCVA 在 TES 后缓慢提高,6 个月后 BCVA 为 20/25。Humphrey 视野测试(VF)和多焦视网膜电图(mfERG)的结果仅略有变化。两年后,BCVA 下降,再次进行相同参数电脉冲的 TES 后视力得到改善。
我们的 BVMD 病例中视力的提高表明 TES 应在其他类型的视网膜营养不良中尝试。需要进一步进行 TES 的临床和实验室研究。