Vasil'ev A V, Vorobeĭchik T A, Gutkin D V, Levitskaia A B, Tutel'ian V A
Vopr Med Khim. 1991 Sep-Oct;37(5):33-5.
Actinomycin D inhibited activation of lysosomal cathepsins A, B, C, D, H and L in peritoneal macrophages, caused by T-dependent antigen (sheep erythrocytes), of mice CBA X C57BL/6 strain. At the same time, the antibiotic stimulated activity of cathepsins A, C, D and H but decreased content of antibody-producing cells in spleen tissue. Inhibition of lysosomal proteinases in macrophages may be responsible for immunodepressive effect of actinomycin D.
