Vasil'ev A V, Konovalova L S, Pletsityĭ K D, Ponomareva L G, Tutel'ian V A
Vopr Med Khim. 1987 Sep-Oct;33(5):81-3.
Total activity of cathepsins A, B, C, D as well as of arylsulfatases A and B were studied in liver, spleen, thymus tissues of rats after peroral administration of vitamin A at a daily dose of 30,000 IU within 3 days and the following immunization with sheep erythrocytes. Under conditions of immunization with T-dependent antigen the immunostimulating effect of vitamin A was accompanied by the distinct activation of lysosomal proteinases in liver and spleen tissues but did not affect the functional state of thymocyte lysosomal apparatus. The reaction of lysosomal hydrolases observed was considered as one of biochemical steps in development of humoral immunity.
在大鼠经口给予每日剂量为30,000国际单位的维生素A，持续3天，随后用绵羊红细胞进行免疫后，研究了组织蛋白酶A、B、C、D以及芳基硫酸酯酶A和B在肝脏、脾脏、胸腺组织中的总活性。在依赖T细胞抗原的免疫条件下，维生素A的免疫刺激作用伴随着肝脏和脾脏组织中溶酶体蛋白酶的明显激活，但不影响胸腺细胞溶酶体装置的功能状态。观察到的溶酶体水解酶反应被认为是体液免疫发展中的生化步骤之一。
