Vasil'ev A V, Konovalova L S, Pletsitnyĭ K D, Ponomareva L G, Tutel'ian V A
Vopr Med Khim. 1988 Mar-Apr;34(2):97-9.
Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.
在伴有维生素B6缺乏的抗原刺激后，研究了大鼠肝脏、脾脏和胸腺组织中组织蛋白酶A、B、C和D的活性、蛋白质半衰期T1/2、脾脏中抗体产生细胞的含量、抗体滴度和补体活性。维生素B6缺乏导致免疫反应明显降低，胸腺中硫醇依赖性蛋白酶的激活受到抑制，而肝脏组织中的酶活性降低。同时，肝脏组织中蛋白质T1/2增加了39%，胸腺中降低了36%。这些数据表明溶酶体硫醇依赖性蛋白酶在免疫发生中的重要性。
