Kravchenko L V, Kuz'mina E E, Avren'eva L I, Pozdniakov A L, Kulakova S N, Levachev M M
Vopr Pitan. 1994(4):13-6.
Wistar male rats received polysynthetic diets incorporating lard or fish of different oxidation degree as the sourse of fat. The feeding lasted 4 weeks. In the liver of rats on fish oil diet the activity of the enzymes of xenobiotic metabolism phase I (monooxigenase system, epoxide hydrolase, carboxyl esterase) and phase II (native and activated UDP-glucuronosyl transferase, glutathione transferase) located both in microsoma membranes and in cytozole was higher than in the animals on lard diet. The enzyme activity was much more enhanced in the use of oxidated fish oil. No effect of fish oil on serum and lysosome enzyme activity and rat hepatic structure was found.
Wistar雄性大鼠摄入含有不同氧化程度的猪油或鱼类作为脂肪来源的多合成饮食。喂养持续4周。在食用鱼油饮食的大鼠肝脏中，位于微粒体膜和细胞溶质中的外源物质代谢I相（单加氧酶系统、环氧化物水解酶、羧酸酯酶）和II相（天然和活化的UDP-葡萄糖醛酸基转移酶、谷胱甘肽转移酶）的酶活性高于食用猪油饮食的动物。在使用氧化鱼油时，酶活性增强得更多。未发现鱼油对血清和溶酶体酶活性以及大鼠肝脏结构有影响。
