Graven-Nielsen Thomas, Arendt-Nielsen Lars
Aalborg Universitet, Institut for Sundhedsvidenskab og Teknologi, Center for Sanse-Motorisk Interaktion.
Ugeskr Laeger. 2007 Jun 18;169(25):2425-7.
Gender differences in response to pain have implications for several chronic pain conditions. Lower pain thresholds to various pain modalities have been reported in females compared to males, and differences in pain sensitivity are found across the menstrual phases. Furthermore, the descending pain control seems less efficient in females. The response to pharmacological interventions, e.g. opioid analgesia or NSAID treatment, may be gender-dependent but more studies are needed. The gender difference in pain sensitivity might partly be linked to the female sex hormones but is also dependent on a complex interaction between psychosocial and physiological factors.
疼痛反应中的性别差异对多种慢性疼痛状况具有影响。与男性相比，女性对各种疼痛模式的疼痛阈值较低，且在月经周期各阶段发现疼痛敏感性存在差异。此外，下行性疼痛控制在女性中似乎效率较低。对药物干预（如阿片类镇痛或非甾体抗炎药治疗）的反应可能存在性别差异，但还需要更多研究。疼痛敏感性的性别差异可能部分与女性性激素有关，但也取决于心理社会因素和生理因素之间的复杂相互作用。
