Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Prog Brain Res. 2010;186:141-57. doi: 10.1016/B978-0-444-53630-3.00009-9.
It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference. Although sex differences in sociocultural, psychological, and experiential factors likely play important roles, evidence largely from animal studies has revealed surprisingly robust and often qualitative sex differences at low levels of the neuraxis. Although not yet able to affect clinical practice, the continued study of sex differences in pain may have important implications for the development of new analgesic strategies.
这是一个临床现实，即女性占慢性疼痛患者的绝大多数，现在从实验室实验中得出共识，即当出现差异时，女性比男性对疼痛更敏感。该领域的研究现在已经开始集中精力寻找这种性别差异的解释。尽管社会文化、心理和经验因素的性别差异可能起着重要作用，但主要来自动物研究的证据表明，在较低的神经轴水平上，存在着惊人的、通常是定性的性别差异。尽管还不能影响临床实践，但继续研究疼痛的性别差异可能对新的镇痛策略的发展具有重要意义。
