富含生长因子的自体制剂治疗慢性皮肤溃疡的有效性。
Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers.
作者信息
Anitua Eduardo, Aguirre José J, Algorta Jaime, Ayerdi Eduardo, Cabezas Ana I, Orive Gorka, Andia Isabel
机构信息
Biotechnology Institute, Vitoria, Spain.
出版信息
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):415-21. doi: 10.1002/jbm.b.30886.
Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF-AB, TGF-beta1, IGF-I, HGF, VEGF-A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open-label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% +/- 22.25% whereas it was 21.48% +/- 33.56% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal.
富血小板自体生长因子制剂（PRGF）是一种富含血小板的少量血浆，由于其能持续释放多种生长因子，包括血小板源性生长因子AB（PDGF-AB）、转化生长因子β1（TGF-β1）、胰岛素样生长因子I（IGF-I）、肝细胞生长因子（HGF）、血管内皮生长因子A（VEGF-A）和表皮生长因子（EGF），因此是加速多种组织伤口愈合的一种新型治疗策略。在本文中，我们对PRGF制剂进行了特性分析，并设计了一项随机开放标签对照试验，以评估PRGF治疗慢性皮肤溃疡的有效性。结果显示，在8周时，PRGF组的平均愈合面积百分比为72.94%±22.25%，而对照组为21.48%±33.56%（p<0.05）。这些结果，结合初步研究的局限性，表明局部应用PRGF在促进慢性溃疡愈合方面比标准治疗更有效。
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