富含生长因子的血浆在皮肤伤口愈合中的应用：家兔实验研究
The use of plasma rich in growth factors on wound healing in the skin: experimental study in rabbits.
作者信息
Molina-Miñano Francesco, López-Jornet Péa, Camacho-Alonso Fabio, Vicente-Ortega Vicente
机构信息
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Spain.
出版信息
Int Wound J. 2009 Apr;6(2):145-8. doi: 10.1111/j.1742-481X.2009.00592.x.
Abstract
The objective of this study was to use autologous plasma rich in growth factors (PRGF) on wound healing in the skin in New Zealand albino rabbits and to study reepithelialisation and inflammation at 7 and 28 days. A prospective study carried out on 20 adult rabbits. Two wounds were made on the in the skin on the back of each animal; one control, and the other in which PRGF was applied. The PRGF preparation was obtained from 10 ml of whole blood. The reepithelialisation and inflammation of wounds were measured at 7 and 28 days. Reepithelialisation improved in skin at 7 days (P = 0.007), with resolution of the inflammatory process (P = 0.005), having significant differences with respect to the control. Therefore, PRGF accelerates reepithelialisation and reduces inflammation at 7 days in skin.
摘要
本研究的目的是在新西兰白化兔的皮肤伤口愈合中使用富含生长因子的自体血浆（PRGF），并研究7天和28天时的再上皮化和炎症情况。对20只成年兔子进行了一项前瞻性研究。在每只动物背部的皮肤上制造两个伤口；一个作为对照，另一个应用PRGF。PRGF制剂取自10毫升全血。在7天和28天时测量伤口的再上皮化和炎症情况。7天时皮肤的再上皮化得到改善（P = 0.007），炎症过程消退（P = 0.005），与对照组相比有显著差异。因此，PRGF在7天时可加速皮肤的再上皮化并减轻炎症。
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