一种通过铜和钯催化的串联交叉偶联反应合成炔基吲哚和苯并呋喃的通用实用方法。
A general and practical method of alkynyl indole and benzofuran synthesis via tandem Cu- and Pd-catalyzed cross-couplings.
作者信息
Nagamochi Masatoshi, Fang Yuan-Qing, Lautens Mark
机构信息
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
出版信息
Org Lett. 2007 Jul 19;9(15):2955-8. doi: 10.1021/ol071370w. Epub 2007 Jun 27.
PMID:17595099
Abstract
A new tandem coupling approach to synthesize 2-alkynyl indoles and benzofurans is described. This reaction utilizes easily accessible gem-dibromovinyl substrates and terminal alkynes and proceeds via Pd/C- and CuI-catalyzed tandem Ullman/Sonogashira couplings.
摘要
描述了一种合成2-炔基吲哚和苯并呋喃的新型串联偶联方法。该反应利用易于获得的偕二溴乙烯基底物和末端炔烃，并通过钯/碳和碘化亚铜催化的串联乌尔曼/ Sonogashira偶联反应进行。
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